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Posted: Friday, November 17, 2017 12:08 AM


Located in Redmond WA, SystImmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor. We are a group of highly experienced immuno-oncology scientists utilizing several technology platforms to develop world class advanced antibody-based drug therapies.

We are seeking a highly motived Senior Associate Scientist / Scientist to preform antibody and antibody drug conjugate purification process development. This individual must be highly-organized, detail-oriented and be able to multitask in a fast-paced and dynamic small company environment.

Responsibilities and requirements:

Participate in pre-clinical and clinical antibody and antibody drug conjugate protein purification process development;

Support and closely work with research, cell-line development, upstream, analytical and formulation groups;

Design and develop scalable and robust purification processes via affinity chromatography, IEC, HIC and CHT, etc;

Perform viral inactivation and viral filtration process development;

Conduct filtration processing using Crossflow and Tangential Flow Filtration techniques;

Responsible to generate low endotoxin production run for pre-clinical studies

Work with wide variety of analytical methods such as SDS-PAGE, HPLC-SEC, CE-SDS, cIEF, HCP and endotoxin analysis;

Effectively coordinate with colleague and research teams;

Keep accurate, detailed and timely records of laboratory work;

Establish relevant cGMP documents to support successful implementation of process technology in clinical/commercial manufacturing operations;

Transfer protein purification processes and documentations to support drug manufacture;

Travel is required;

This position requires lifting of up to 50 lbs occasionally

Education and Experience:
Ph.D. PhD; MS; BS in Protein Science, Biochemistry or a related field with 2+ years (PhD); 6+ years (MS); 8+ years (BS) of relevant academic and/or pharmaceutical or biotech experience

A good understanding of protein purification mechanism and protein analysis;

Hands-on experience of:
-Purification Process Development

- ÄKTA Protein Purification Systems and Unicorn software

- Crossflow and Tangential Flow Filtration techniques

- Column packing / unpacking

- Viral inactivation and viral filtration process development / Viral clearance study

- Low endotoxin production run
- Process scale-down/scale-up

Setup and run analytical experiment

Ability to design and execute experiments independently

SystImmune offers a competitive salary and generous benefits package, including a health/dental/vision care package, employer retirement match, and paid time off and holidays!

To Apply: Interested applicants should send their CV and cover letter to

• Location: Redmond, Washington, United States, Seattle

• Post ID: 56491307 seattle is an interactive computer service that enables access by multiple users and should not be treated as the publisher or speaker of any information provided by another information content provider. © 2018