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Posted: Friday, November 17, 2017 12:08 AM

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Description
Located in Redmond WA, SystImmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor. We are a group of highly experienced immuno-oncology scientists utilizing several technology platforms to develop world class advanced antibody-based drug therapies.


We are seeking a highly motived Senior Associate Scientist / Scientist to preform antibody and antibody drug conjugate purification process development. This individual must be highly-organized, detail-oriented and be able to multitask in a fast-paced and dynamic small company environment.


Responsibilities and requirements:


Participate in pre-clinical and clinical antibody and antibody drug conjugate protein purification process development;

Support and closely work with research, cell-line development, upstream, analytical and formulation groups;

Design and develop scalable and robust purification processes via affinity chromatography, IEC, HIC and CHT, etc;

Perform viral inactivation and viral filtration process development;

Conduct filtration processing using Crossflow and Tangential Flow Filtration techniques;

Responsible to generate low endotoxin production run for pre-clinical studies

Work with wide variety of analytical methods such as SDS-PAGE, HPLC-SEC, CE-SDS, cIEF, HCP and endotoxin analysis;

Effectively coordinate with colleague and research teams;

Keep accurate, detailed and timely records of laboratory work;

Establish relevant cGMP documents to support successful implementation of process technology in clinical/commercial manufacturing operations;

Transfer protein purification processes and documentations to support drug manufacture;

Travel is required;

This position requires lifting of up to 50 lbs occasionally

Education and Experience:
Ph.D. PhD; MS; BS in Protein Science, Biochemistry or a related field with 2+ years (PhD); 6+ years (MS); 8+ years (BS) of relevant academic and/or pharmaceutical or biotech experience

A good understanding of protein purification mechanism and protein analysis;

Hands-on experience of:
-Purification Process Development

- ÄKTA Protein Purification Systems and Unicorn software

- Crossflow and Tangential Flow Filtration techniques

- Column packing / unpacking

- Viral inactivation and viral filtration process development / Viral clearance study

- Low endotoxin production run
- Process scale-down/scale-up


Setup and run analytical experiment

Ability to design and execute experiments independently

SystImmune offers a competitive salary and generous benefits package, including a health/dental/vision care package, employer retirement match, and paid time off and holidays!

To Apply: Interested applicants should send their CV and cover letter to hr@systimmune.com

• Location: Redmond, Washington, United States, Seattle

• Post ID: 56491307 seattle
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